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The PEI was founded from the NIHR Great Ormond Street Hospital Biomedical Research Centre (GOSH BRC) award in 2022, and is a collaboration between Great Ormond Street, Alder Hey, Birmingham and Sheffield Children’s Hospitals. The PEI delivers a programme of early translational research to improve the lives of children with rare and complex conditions. We hope this landmark event will serve as a catalyst for the PEI to maximize the value of the NIHR investment, driving innovative paediatric healthcare research collaborations across the UK.